RASA3 Antibody
| Code | Size | Price |
|---|
| PSI-60-278-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Ras GTPase-activating protein 3, GAP1(IP4BP), Ins P4-binding protein, RASA3
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is member of the GAP1
family of GTPase-activating proteins. The gene product stimulates
the GTPase activity of normal RAS p21 but not its oncogenic
counterpart. Acting as a suppressor of RAS function, the protein
enhances the weak intrinsic GTPase activity of RAS proteins
resulting in the inactive GDP-bound form of RAS, thereby allowing
control of cellular proliferation and differentiation. This family
member is an inositol 1,3,4,5-tetrakisphosphate-binding protein,
like the closely related RAS p21 protein activator 2. The two
family members have distinct pleckstrin-homology domains, with this
particular member having a domain consistent with its localization
to the plasma membrane.
Background References:
- Kupzig, S., et al. Mol. Cell. Biol. 29(14):3929-3940(2009)
- Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
- Walker, S.A., et al. J. Biol. Chem. 277(50):48779-48785(2002)
- Koehler, J.A., et al. Biochem. Biophys. Res. Commun. 283(4):888-895(2001)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RASA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 594-623 amino acids from the C-terminal region of human RASA3.
NCBI Gene ID #:
22821
NCBI Official Name:
Ras GTPase-activating protein 3
NCBI Official Symbol:
RASA3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
96 kDa
Protein Accession #:
Q14644
Protein GI Number:
206729910
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q14644
User NOte:
Optimal dilutions for each application to be determined by the researcher.