ACK1 Antibody
| Code | Size | Price |
|---|
| PSI-57-363-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a tyrosine kinase that binds Cdc42Hs in
its GTP-bound form and inhibits both the intrinsic and
GTPase-activating protein (GAP)-stimulated GTPase activity of
Cdc42Hs. This binding is mediated by a unique sequence of 47 amino
acids C-terminal to an SH3 domain. The protein may be involved in a
regulatory mechanism that sustains the GTP-bound active form of
Cdc42Hs and which is directly linked to a tyrosine phosphorylation
signal transduction pathway. Several alternatively spliced
transcript variants have been identified from this gene, but the
full-length nature of only two transcript variants has been
determined.
Background References:
- Mahajan, K., et al. J. Cell. Physiol. 224(2):327-333(2010)
- Chua, B.T., et al. Mol Oncol 4(4):323-334(2010)
- Prieto-Echague, V., et al. J. Biol. Chem. 285(14):10605-10615(2010)
- Lin, Q., et al. Mol. Cell. Biol. 30(6):1541-1554(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-290 amino acids from the Central region of human ACK1.
NCBI Gene ID #:
10188
NCBI Official Name:
Activated CDC42 kinase 1
NCBI Official Symbol:
TNK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
115 kDa
Protein Accession #:
Q07912
Protein GI Number:
229462980
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q07912
User NOte:
Optimal dilutions for each application to be determined by the researcher.