DSG2 Antibody
| Code | Size | Price |
|---|
| PSI-57-710-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Desmoglein-2, Cadherin family member 5, HDGC, DSG2, CDHF5
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Desmosomes are cell-cell junctions between epithelial,
myocardial, and certain other cell types. This gene product is a
calcium-binding transmembrane glycoprotein component of desmosomes
in vertebrate epithelial cells. Currently, three desmoglein
subfamily members have been identified and all are members of the
cadherin cell adhesion molecule superfamily. These desmoglein gene
family members are located in a cluster on chromosome 18. This
second family member is expressed in colon, colon carcinoma, and
other simple and stratified epithelial-derived cell lines.
Mutations in this gene have been associated with arrhythmogenic
right ventricular dysplasia, familial, 10.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Fressart, V., et al. Europace 12(6):861-868(2010)
- Schlegel, N., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (5), G774-G783 (2010) :
- Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-857 amino acids from the C-terminal region of human DSG2.
NCBI Gene ID #:
1829
NCBI Official Name:
Desmoglein-2
NCBI Official Symbol:
DSG2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
122 kDa
Protein Accession #:
Q14126
Protein GI Number:
148876773
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q14126
User NOte:
Optimal dilutions for each application to be determined by the researcher.