Desmin Antibody

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ProSci
Product Code: PSI-57-618
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-57-618-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DES antibody detected the DES protein (arrow).
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DES/Desmin (Muscle Cell Marker) Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DES/Desmin (Muscle Cell Marker) Antibody for immunohistochemistry.
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Western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DES antibody detected the DES protein (arrow).
DES/Desmin (Muscle Cell Marker) Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DES/Desmin (Muscle Cell Marker) Antibody for immunohistochemistry.

Documents

Further Information

Additional Names:
Desmin, DES
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq].
Background References:
  • Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
  • van Spaendonck-Zwarts, K., et al. Clin. Genet. (2010) In press :
  • Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
  • Bar, H., et al. J. Mol. Biol. 397(5):1188-1198(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat
Immunogen:
This Desmin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-359 amino acids from the C-terminal region of human Desmin.
NCBI Gene ID #:
1674
NCBI Official Name:
Desmin
NCBI Official Symbol:
DES
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
Protein Accession #:
P17661
Protein GI Number:
6686280
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
P17661
User NOte:
Optimal dilutions for each application to be determined by the researcher.