CTTN Antibody
| Code | Size | Price |
|---|
| PSI-57-227-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene is overexpressed in breast cancer and squamous
cell carcinomas of the head and neck. The encoded protein is
localized in the cytoplasm and in areas of the cell-substratum
contacts. This gene has two roles: (1) regulating the interactions
between components of adherens-type junctions and (2) organizing
the cytoskeleton and cell adhesion structures of epithelia and
carcinoma cells. During apoptosis, the encoded protein is degraded
in a caspase-dependent manner. The aberrant regulation of this gene
contributes to tumor cell invasion and metastasis. Three splice
variants that encode different isoforms have been identified for
this gene.
Background References:
- Croucher, D.R., et al. Mol. Cell. Biol. 30(21):5057-5070(2010)
- Eiseler, T., et al. J. Biol. Chem. 285(24):18672-18683(2010)
- Xu, X.Z., et al. Mod. Pathol. 23(2):187-196(2010)
- Saitoh, Y., et al. Int. J. Oncol. 35(6):1277-1288(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken
Immunogen:
This CTTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the Central region of human CTTN.
NCBI Gene ID #:
2017
NCBI Official Name:
Src substrate cortactin
NCBI Official Symbol:
CTTN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
62 kDa
Protein Accession #:
Q14247
Protein GI Number:
215273892
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q14247
User NOte:
Optimal dilutions for each application to be determined by the researcher.