HYAL1 Antibody
| Code | Size | Price |
|---|
| PSI-58-067-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a lysosomal hyaluronidase.
Hyaluronidases intracellularly degrade hyaluronan, one of the major
glycosaminoglycans of the extracellular matrix. Hyaluronan is
thought to be involved in cell proliferation, migration and
differentiation. This enzyme is active at an acidic pH and is the
major hyaluronidase in plasma. Mutations in this gene are
associated with mucopolysaccharidosis type IX, or hyaluronidase
deficiency. The gene is one of several related genes in a region of
chromosome 3p21.3 associated with tumor suppression. Multiple
transcript variants encoding different isoforms have been found for
this gene.
Background References:
- Lanktree, M.B., et al. Blood 116(12):2160-2163(2010)
- Gasingirwa, M.C., et al. Biochem. J. 430(2):305-313(2010)
- Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HYAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human HYAL1.
NCBI Gene ID #:
3373
NCBI Official Name:
Hyaluronidase-1
NCBI Official Symbol:
HYAL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa
Protein Accession #:
Q12794
Protein GI Number:
74735617
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q12794
User NOte:
Optimal dilutions for each application to be determined by the researcher.