Activin A Receptor Type IC Antibody
| Code | Size | Price |
|---|
| PSI-62-664-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, ACVR1C (HGNC:18123)
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IHC-P starting dilution is: 1:50~100
Background:
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
Background References:
- Munir, S., et al., J. Biol. Chem. 279(30):31277-31286 (2004).
- Kim, B.C., et al., J. Biol. Chem. 279(27):28458-28465 (2004).
- Roberts, H.J., et al., Biol. Reprod. 68(5):1719-1726 (2003).
- Tsuchida, K., et al., Mol. Cell. Endocrinol. 220 (1-2), 59-65 (2004) (): ().
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This Activin A Receptor Type IC (ACVR1C) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human Activin A Receptor Type IC (ACVR1C).
NCBI Gene ID #:
130399
NCBI Official Name:
Activin receptor type-1C
NCBI Official Symbol:
ACVR1C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Protein Accession #:
Q8NER5
Protein GI Number:
74762565
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q8NER5
User NOte:
Optimal dilutions for each application to be determined by the researcher.