ADCY2 Antibody

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ProSci
Product Code: PSI-61-479
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-61-479-400ul400ul£626.00
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis of anti-ADCY2 Pab in Jurkat cell line lysates (35ug/lane).
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Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ADCY2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
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Western blot analysis of anti-ADCY2 Pab in Jurkat cell line lysates (35ug/lane).
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ADCY2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Documents

Further Information

Additional Names:
Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, ADCY2, KIAA1060
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
Background:
ADCY2 is a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate(cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
Background References:
  • Uhl,G.R.,Arch. Gen. Psychiatry 65 (6), 683-693 (2008)
  • Ludwig,M.G.,J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002)
  • Cote,M., J. Clin. Endocrinol. Metab. 86 (9), 4495-4503 (2001)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ADCY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-969 amino acids from the C-terminal region of human ADCY2.
NCBI Gene ID #:
108
NCBI Official Name:
Adenylate cyclase type 2
NCBI Official Symbol:
ADCY2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
124 kDa
Protein Accession #:
Q08462
Protein GI Number:
118572617
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q08462
User NOte:
Optimal dilutions for each application to be determined by the researcher.