HYAL2 Antibody
| Code | Size | Price |
|---|
| PSI-55-374-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Background:
This gene encodes a weak acid-active hyaluronidase. The
encoded protein is similar in structure to other more active
hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major
glycosaminoglycans of the extracellular matrix. Hyaluronan and
fragments of hyaluronan are thought to be involved in cell
proliferation, migration and differentiation. Although it was
previously thought to be a lysosomal hyaluronidase that is active
at a pH below 4, the encoded protein is likely a GPI-anchored cell
surface protein. This hyaluronidase serves as a receptor for the
oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of
several related genes in a region of chromosome 3p21.3 associated
with tumor suppression. This gene encodes two alternatively spliced
transcript variants which differ only in the 5' UTR.
Background References:
- Monzon, M.E., et al. J. Biol. Chem. 285(34):26126-26134(2010)
- Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)
- de la Motte, C., et al. Am. J. Pathol. 174(6):2254-2264(2009)
- Nykopp, T.K., et al. BMC Cancer 9, 143 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-412 amino acids from the C-terminal region of human HYAL2.
NCBI Gene ID #:
8692
NCBI Official Name:
Hyaluronidase-2
NCBI Official Symbol:
HYAL2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
Protein Accession #:
Q12891
Protein GI Number:
311033483
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q12891
User NOte:
Optimal dilutions for each application to be determined by the researcher.