FZD7 Antibody
| Code | Size | Price |
|---|
| PSI-59-598-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Frizzled-7, Fz-7, hFz7, FzE3, FZD7
Application Note:
For WB starting dilution is: 1:1000
Background:
Members of the 'frizzled' gene family encode
7-transmembrane domain proteins that are receptors for Wnt
signaling proteins. The FZD7 protein contains an N-terminal signal
sequence, 10 cysteine residues typical of the cysteine-rich
extracellular domain of Fz family members, 7 putative transmembrane
domains, and an intracellular C-terminal tail with a PDZ
domain-binding motif. FZD7 gene expression may downregulate APC
function and enhance beta-catenin-mediated signals in poorly
differentiated human esophageal carcinomas.
Background References:
- Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
- Vincan, E., et al. Dev. Dyn. 239(1):311-317(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
- Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken, Mouse
Immunogen:
This FZD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-229 amino acids from the Central region of human FZD7.
NCBI Gene ID #:
8324
NCBI Official Name:
Frizzled-7
NCBI Official Symbol:
FZD7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
64 kDa
Protein Accession #:
O75084
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction,Growth Factor
Swissprot #:
O75084
User NOte:
Optimal dilutions for each application to be determined by the researcher.