PCSK4 Antibody
| Code | Size | Price |
|---|
| PSI-58-777-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Proprotein convertase subtilisin/kexin type 4, 3421-, Proprotein convertase 4, PC4, PCSK4 {ECO:0000312|EMBL:AAH363541}
Application Note:
For WB starting dilution is: 1:1000
Background:
Proprotein convertases, including PCSK4, are
calcium-dependent serine proteases related to bacterial subtilisins
and to yeast kexin. These enzymes process precursor proteins to
their active forms by selective cleavage of the polypeptide at
sites following paired basic amino acids. In mammals, this family
comprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM
600488), furin (FUR; MIM 136950), and PACE4 (MIM 167405).
Substrates for these enzymes range from prohormones to precursors
for growth factors to cell surface receptors and viral surface
glycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied by
OMIM].
Background References:
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Batta, K., et al. J. Mol. Biol. 385(3):788-799(2009)
- Qiu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 102(31):11047-11052(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PCSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the N-terminal region of human PCSK4.
NCBI Gene ID #:
54760
NCBI Official Name:
Proprotein convertase subtilisin/kexin type 4
NCBI Official Symbol:
PCSK4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
83 kDa
Protein Accession #:
Q6UW60
Protein GI Number:
296439263
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q6UW60
User NOte:
Optimal dilutions for each application to be determined by the researcher.