PITX2 Antibody
| Code | Size | Price |
|---|
| PSI-57-422-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the RIEG/PITX homeobox
family, which is in the bicoid class of homeodomain proteins. The
encoded protein acts as a transcription factor and regulates
procollagen lysyl hydroxylase gene expression. This protein plays a
role in the terminal differentiation of somatotroph and lactotroph
cell phenotypes, is involved in the development of the eye, tooth
and abdominal organs, and acts as a transcriptional regulator
involved in basal and hormone-regulated activity of prolactin.
Mutations in this gene are associated with Axenfeld-Rieger
syndrome, iridogoniodysgenesis syndrome, and sporadic cases of
Peters anomaly. A similar protein in other vertebrates is involved
in the determination of left-right asymmetry during development.
Alternatively spliced transcript variants encoding distinct
isoforms have been described.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Banez, L.L., et al. J. Urol. 184(1):149-156(2010)
- Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
- Ellinor, P.T., et al. Nat. Genet. 42(3):240-244(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PITX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-71 amino acids from the N-terminal region of human PITX2.
NCBI Gene ID #:
5308
NCBI Official Name:
Pituitary homeobox 2
NCBI Official Symbol:
PITX2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
35 kDa
Protein Accession #:
Q99697
Protein GI Number:
6174907
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q99697
User NOte:
Optimal dilutions for each application to be determined by the researcher.