ICMT Antibody
| Code | Size | Price |
|---|
| PSI-61-422-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine carboxylmethyltransferase, Prenylated protein carboxyl methyltransferase, PPMT, Prenylcysteine carboxyl methyltransferase, pcCMT, ICMT, PCCMT
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing results in two transcript variants encoding different isoforms.
Background References:
- Bergo, M.O., et al., J. Clin. Invest. 113(4):539-550 (2004).
- Ahmad, M., et al., Arterioscler. Thromb. Vasc. Biol. 22(5):759-764 (2002).
- Van Dessel, G.A., et al., Int. J. Biochem. Cell Biol. 34(5):477-486 (2002).
- Dai, Q., et al., J. Biol. Chem. 273(24):15030-15034 (1998).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ICMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-284 amino acids from the C-terminal region of human ICMT.
NCBI Gene ID #:
23463
NCBI Official Name:
Protein-S-isoprenylcysteine O-methyltransferase
NCBI Official Symbol:
ICMT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
32 kDa
Protein Accession #:
O60725
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle
Swissprot #:
O60725
User NOte:
Optimal dilutions for each application to be determined by the researcher.