FBXW5 Antibody
| Code | Size | Price |
|---|
| PSI-60-576-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
F-box/WD repeat-containing protein 5, F-box and WD-40 domain-containing protein 5, FBXW5, FBW5
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the F-box protein family,
members of which are characterized by an approximately 40 amino
acid motif, the F-box. The F-box proteins constitute one of the
four subunits of ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent
ubiquitination. The F-box proteins are divided into three classes:
Fbws containing WD-40 domains, Fbls containing leucine-rich
repeats, and Fbxs containing either different protein-protein
interaction modules or no recognizable motifs. The protein encoded
by this gene contains WD-40 domains, in addition to an F-box motif,
so it belongs to the Fbw class. Alternatively spliced transcript
variants encoding distinct isoforms have been identified for this
gene, however, they were found to be nonsense-mediated mRNA decay
(NMD) candidates, hence not represented.
Background References:
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Minoda, Y., et al. Biochem. Biophys. Res. Commun. 381(3):412-417(2009)
- Hu, J., et al. Genes Dev. 22(7):866-871(2008)
- Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FBXW5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-350 amino acids from the Central region of human FBXW5.
NCBI Gene ID #:
54461
NCBI Official Name:
F-box/WD repeat-containing protein 5
NCBI Official Symbol:
FBXW5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
64 kDa
Protein Accession #:
Q969U6
Protein GI Number:
44887886
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q969U6
User NOte:
Optimal dilutions for each application to be determined by the researcher.