RNF34 Antibody
| Code | Size | Price |
|---|
| PSI-58-611-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
E3 ubiquitin-protein ligase RNF34, 632- {ECO:0000269|PubMed:25012219, ECO:0000269|Ref13}, Caspase regulator CARP1, Caspases-8 and -10-associated RING finger protein 1, CARP-1, FYVE-RING finger protein Momo, RNF34 (HGNC:17297)
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene contains a RINF finger, a
motif known to be involved in protein-protein and protein-DNA
interactions. This protein interacts with DNAJA3/hTid-1, which is a
DnaJ protein reported to function as a modulator of apoptosis.
Overexpression of this gene in Hela cells was shown to confer the
resistance to TNF-alpha induced apoptosis, suggesting an
anti-apoptotic function of this protein. This protein can be
cleaved by caspase-3 during the induction of apoptosis.
Alternatively spliced transcript variants encoding distinct
isoforms have been reported.
Background References:
- Erlbruch, A., et al. Proteomics 10(16):2890-2900(2010)
- Yang, W., et al. Cell Cycle 7(5):670-682(2008)
- Yang, W., et al. J. Biol. Chem. 282(5):3273-3281(2007)
- Konishi, T., et al. Mol. Cancer Ther. 4(5):743-750(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This RNF34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human RNF34.
NCBI Gene ID #:
80196
NCBI Official Name:
E3 ubiquitin-protein ligase RNF34
NCBI Official Symbol:
RNF34
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
Q969K3
Protein GI Number:
74760679
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q969K3
User NOte:
Optimal dilutions for each application to be determined by the researcher.