FBXW4 Antibody
| Code | Size | Price |
|---|
| PSI-60-930-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
F-box/WD repeat-containing protein 4, Dactylin, F-box and WD-40 domain-containing protein 4, FBXW4, FBW4, SHFM3
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is a member of the F-box/WD-40 gene family,
which recruit specific target proteins through their WD-40
protein-protein binding domains for ubiquitin mediated degradation.
In mouse, a highly similar protein is thought to be responsible for
maintaining the apical ectodermal ridge of developing limb buds;
disruption of the mouse gene results in the absence of central
digits, underdeveloped or absent metacarpal/metatarsal bones and
syndactyly. This phenotype is remarkably similar to split
hand-split foot malformation in humans, a clinically heterogeneous
condition with a variety of modes of transmission. An autosomal
recessive form has been mapped to the chromosomal region where this
gene is located, and complex rearrangements involving duplications
of this gene and others have been associated with the condition. A
pseudogene of this locus has been mapped to one of the introns of
the BCR gene on chromosome 22.
Background References:
- Everman, D.B., et al. Am. J. Med. Genet.140(13):1375-1383(2006)
- Kano, H., et al. Hum. Genet. 118 (3-4), 477-483 (2005) :
- Kang, Y.S., et al. Mol. Cells 17(3):397-403(2004)
- Deloukas, P., et al. Nature 429(6990):375-381(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FBXW4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human FBXW4.
NCBI Gene ID #:
6468
NCBI Official Name:
F-box/WD repeat-containing protein 4
NCBI Official Symbol:
FBXW4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
Protein Accession #:
P57775
Protein GI Number:
13124191
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
P57775
User NOte:
Optimal dilutions for each application to be determined by the researcher.