PSMD12 Antibody
Code | Size | Price |
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PSI-60-863-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
26S proteasome non-ATPase regulatory subunit 12, 26S proteasome regulatory subunit RPN5, 26S proteasome regulatory subunit p55, PSMD12
Application Note:
For WB starting dilution is: 1:1000
Background:
The 26S proteasome is a multicatalytic proteinase complex
with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28
non-identical subunits; 2 rings are composed of 7 alpha subunits
and 2 rings are composed of 7 beta subunits. The 19S regulator is
composed of a base, which contains 6 ATPase subunits and 2
non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. This gene encodes a
non-ATPase subunit of the 19S regulator. A pseudogene has been
identified on chromosome 3.
Background References:
- Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
- Gandhi, T.K., et al. Nat. Genet. 38(3):285-293(2006)
- Listovsky, T., et al. EMBO J. 23(7):1619-1626(2004)
- Bouwmeester, T., et al. Nat. Cell Biol. 6(2):97-105(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This PSMD12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-304 amino acids from the Central region of human PSMD12.
NCBI Gene ID #:
5718
NCBI Official Name:
26S proteasome non-ATPase regulatory subunit 12
NCBI Official Symbol:
PSMD12
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Protein Accession #:
O00232
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
O00232
User NOte:
Optimal dilutions for each application to be determined by the researcher.