FBXO11 Antibody
| Code | Size | Price |
|---|
| PSI-58-800-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11, FBX11, PRMT9, VIT1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the F-box protein family
which is characterized by an approximately 40 amino acid motif, the
F-box. The F-box proteins constitute one of the four subunits of
ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
which function in phosphorylation-dependent ubiquitination. The
F-box proteins are divided into 3 classes: Fbws containing WD-40
domains, Fbls containing leucine-rich repeats, and Fbxs containing
either different protein-protein interaction modules or no
recognizable motifs. The protein encoded by this gene belongs to
the Fbxs class. It can function as an arginine methyltransferase
that symmetrically dimethylates arginine residues, and it acts as
an adaptor protein to mediate the neddylation of p53, which leads
to the suppression of p53 function. This gene is known to be
down-regulated in melanocytes from patients with vitiligo, a skin
disorder that results in depigmentation. Polymorphisms in this gene
are associated with chronic otitis media with effusion and
recurrent otitis media (COME/ROM), a hearing loss disorder, and the
knockout of the homologous mouse gene results in the deaf mouse
mutant Jeff (Jf), a single gene model of otitis media.
Alternatively spliced transcript variants encoding distinct
isoforms have been identified for this gene.
Background References:
- Guan, C., et al. Int. J. Mol. Med. 26(1):57-65(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Guan, C.P., et al. Zhonghua Yi Xue Za Zhi 90(16):1126-1130(2010)
- Abida, W.M., et al. J. Biol. Chem. 282(3):1797-1804(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FBXO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human FBXO11.
NCBI Gene ID #:
80204
NCBI Official Name:
F-box only protein 11
NCBI Official Symbol:
FBXO11
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
104 kDa
Protein Accession #:
Q86XK2
Protein GI Number:
124012093
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q86XK2
User NOte:
Optimal dilutions for each application to be determined by the researcher.