FBXL12 Antibody

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ProSci
Product Code: PSI-59-517
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-59-517-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).
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Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).

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Further Information

Additional Names:
F-box/LRR-repeat protein 12, F-box and leucine-rich repeat protein 12, F-box protein FBL12, FBXL12, FBL12
Application Note:
For WB starting dilution is: 1:1000
Background:
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].
Background References:
  • Lamesch, P., et al. Genomics 89(3):307-315(2007)
  • Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
  • Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)
  • Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This FBXL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-303 amino acids from the C-terminal region of human FBXL12.
NCBI Gene ID #:
54850
NCBI Official Name:
F-box/LRR-repeat protein 12
NCBI Official Symbol:
FBXL12
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
37 kDa
Protein Accession #:
Q9NXK8
Protein GI Number:
38257780
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q9NXK8
User NOte:
Optimal dilutions for each application to be determined by the researcher.