PCSK7 Antibody
| Code | Size | Price |
|---|
| PSI-57-440-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Proprotein convertase subtilisin/kexin type 7, 3421-, Lymphoma proprotein convertase, Prohormone convertase 7, Proprotein convertase 7, PC7, Proprotein convertase 8, PC8, hPC8, Subtilisin/kexin-like protease PC7, PCSK7, LPC, PC7, PC8, SPC7
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene belongs to the
subtilisin-like proprotein convertase family. The members of this
family are proprotein convertases that process latent precursor
proteins into their biologically active products. This encoded
protein is a calcium-dependent serine endoprotease. It is
structurally related to its family members, PACE and PACE4. This
protein is concentrated in the trans-Golgi network, associated with
the membranes, and is not secreted. It can process proalbumin and
is thought to be responsible for the activation of HIV envelope
glycoproteins gp160 and gp140. This gene has been implicated in the
transcriptional regulation of housekeeping genes. Multiple
alternatively spliced transcripts are described for this gene but
their full length nature is not yet known. Downstream of this
gene's map location at 11q23-q24, nucleotides that match part of
this gene's 3' end are duplicated and inverted. A translocation
breakpoint associated with lymphoma occurs between this gene and
its inverted counterpart.
Background References:
- Leonhardt, R.M., et al. J. Immunol. 184(6):2985-2998(2010)
- McColl, B.K., et al. FASEB J. 21(4):1088-1098(2007)
- Bruzzaniti, A., et al. Peptides 23(5):863-875(2002)
- Fugere, M., et al. J. Biol. Chem. 277(10):7648-7656(2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PCSK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human PCSK7.
NCBI Gene ID #:
9159
NCBI Official Name:
Proprotein convertase subtilisin/kexin type 7
NCBI Official Symbol:
PCSK7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
86 kDa
Protein Accession #:
Q16549
Protein GI Number:
205830663
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q16549
User NOte:
Optimal dilutions for each application to be determined by the researcher.