SMC1A Antibody
| Code | Size | Price |
|---|
| PSI-57-109-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb18, SMC1A, DXS423E, KIAA0178, SB18, SMC1, SMC1L1
Application Note:
For WB starting dilution is: 1:1000
Background:
Proper cohesion of sister chromatids is a prerequisite for
the correct segregation of chromosomes during cell division. The
cohesin multiprotein complex is required for sister chromatid
cohesion. This complex is composed partly of two structural
maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2
or the protein encoded by this gene. Most of the cohesin complexes
dissociate from the chromosomes before mitosis, although those
complexes at the kinetochore remain. Therefore, the encoded protein
is thought to be an important part of functional kinetochores. In
addition, this protein interacts with BRCA1 and is phosphorylated
by ATM, indicating a potential role for this protein in DNA repair.
This gene, which belongs to the SMC gene family, is located in an
area of the X-chromosome that escapes X inactivation. [provided by
RefSeq].
Background References:
- Limongelli, G., et al. Am. J. Med. Genet.152A (8), 2127-2129 (2010) :
- Homme, C., et al. Oncol. Rep. 24(1):47-56(2010)
- Pie, J., et al. Am. J. Med. Genet.152A (4), 924-929 (2010) :
- Wong, R.W. Cell Cycle 9(1):198-200(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This SMC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the N-terminal region of human SMC1A.
NCBI Gene ID #:
8243
NCBI Official Name:
Structural maintenance of chromosomes protein 1A
NCBI Official Symbol:
SMC1A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
143 kDa
Protein Accession #:
Q14683
Protein GI Number:
29336622
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q14683
User NOte:
Optimal dilutions for each application to be determined by the researcher.