DMTF1 Antibody
| Code | Size | Price |
|---|
| PSI-59-362-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a transcription factor that contains a
cyclin D-binding domain, three central Myb-like repeats, and two
flanking acidic transactivation domains at the N- and C-termini.
The encoded protein is induced by the oncogenic Ras signaling
pathway and functions as a tumor suppressor by activating the
transcription of ARF and thus the ARF-p53 pathway to arrest cell
growth or induce apoptosis. It also activates the transcription of
aminopeptidase N and may play a role in hematopoietic cell
differentiation. The transcriptional activity of this protein is
regulated by binding of D-cyclins. This gene is hemizygously
deleted in approximately 40% of human non-small-cell lung cancer
and is a potential prognostic and gene-therapy target for
non-small-cell lung cancer. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
Background References:
- Liu, Y., et al. Mol. Psychiatry (2010) In press :
- Sugiyama, T., et al. Expert Rev. Mol. Diagn. 8(4):435-447(2008)
- Inoue, K., et al. Cancer Res. 68(12):4487-4490(2008)
- Tschan, M.P., et al. Leukemia 22(5):1087-1090(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This DMTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-616 amino acids from the C-terminal region of human DMTF1.
NCBI Gene ID #:
9988
NCBI Official Name:
Cyclin-D-binding Myb-like transcription factor 1
NCBI Official Symbol:
DMTF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
84 kDa
Protein Accession #:
Q9Y222
Protein GI Number:
74762040
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q9Y222
User NOte:
Optimal dilutions for each application to be determined by the researcher.