SERPINB8 Antibody
| Code | Size | Price |
|---|
| PSI-60-851-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Serpin B8, Cytoplasmic antiproteinase 2, CAP-2, CAP2, Peptidase inhibitor 8, PI-8, SERPINB8, PI8
Application Note:
For WB starting dilution is: 1:1000
Background:
The superfamily of high molecular weight serine proteinase
inhibitors (serpins) regulate a diverse set of intracellular and
extracellular processes such as complement activation,
fibrinolysis, coagulation, cellular differentiation, tumor
suppression, apoptosis, and cell migration. Serpins are
characterized by well-conserved a tertiary structure that consists
of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989
[PubMed 2690952]). A critical portion of the molecule, the reactive
center loop connects beta sheets A and C. Protease inhibitor-8
(PI8; SERPINB8) is a member of the ov-serpin subfamily, which,
relative to the archetypal serpin PI1 (MIM 107400), is
characterized by a high degree of homology to chicken ovalbumin,
lack of N- and C-terminal extensions, absence of a signal peptide,
and a serine rather than an asparagine residue at the penultimate
position (summary by Bartuski et al., 1997 [PubMed
9268635]).
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- de Koning, P.J., et al. Pancreas 38(4):461-467(2009)
- Luke, M.M., et al. Stroke 40(2):363-368(2009)
- Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SERPINB8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-301 amino acids from the C-terminal region of human SERPINB8.
NCBI Gene ID #:
5271
NCBI Official Name:
Serpin B8
NCBI Official Symbol:
SERPINB8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
43 kDa
Protein Accession #:
P50452
Protein GI Number:
212276474
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
P50452
User NOte:
Optimal dilutions for each application to be determined by the researcher.