HERC3 Antibody
| Code | Size | Price |
|---|
| PSI-60-595-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Probable E3 ubiquitin-protein ligase HERC3, 632-, HECT domain and RCC1-like domain-containing protein 3, HERC3, KIAA0032
Application Note:
For WB starting dilution is: 1:1000
Background:
HERC3 belongs to the HERC family of ubiquitin ligases, all
of which contain a HECT domain and at least 1 RCC1 (MIM
179710)-like domain (RLD). The 350-amino acid HECT domain is
predicted to catalyze the formation of a thioester with ubiquitin
before transferring it to a substrate, and the RLD is predicted to
act as a guanine nucleotide exchange factor for small G proteins
(Hochrainer et al., 2005 [PubMed 15676274]).
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Hochrainer, K., et al. Genomics 85(2):153-164(2005)
- Cruz, C., et al. FEBS Lett. 488 (1-2), 74-80 (2001) :
- Cruz, C., et al. Cytogenet. Cell Genet. 87 (3-4), 263-264 (1999) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HERC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-77 amino acids from the N-terminal region of human HERC3.
NCBI Gene ID #:
8916
NCBI Official Name:
Probable E3 ubiquitin-protein ligase HERC3
NCBI Official Symbol:
HERC3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
117 kDa
Protein Accession #:
Q15034
Protein GI Number:
2495699
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q15034
User NOte:
Optimal dilutions for each application to be determined by the researcher.