RNF128 Antibody
| Code | Size | Price |
|---|
| PSI-60-487-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
E3 ubiquitin-protein ligase RNF128, 632-, Gene related to anergy in lymphocytes protein, GRAIL, RING finger protein 128, RNF128
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a type I transmembrane
protein that localizes to the endocytic pathway. This protein
contains a RING zinc-finger motif and has been shown to possess E3
ubiquitin ligase activity. Expression of this gene in retrovirally
transduced T cell hybridoma significantly inhibits
activation-induced IL2 and IL4 cytokine production. Induced
expression of this gene was observed in anergic CD4(+) T cells,
which suggested a role in the induction of anergic phenotype.
Alternatively spliced transcript variants encoding distinct
isoforms have been reported.
Background References:
- Su, L.L., et al. J. Immunol. 183(1):438-444(2009)
- Lin, J.T., et al. J. Immunol. 182(10):5919-5928(2009)
- Lineberry, N., et al. J. Biol. Chem. 283(42):28497-28505(2008)
- Egawa, S., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 295 (1), G163-G169 (2008) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This RNF128 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human RNF128.
NCBI Gene ID #:
79589
NCBI Official Name:
E3 ubiquitin-protein ligase RNF128
NCBI Official Symbol:
RNF128
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Protein Accession #:
Q8TEB7
Protein GI Number:
74751443
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q8TEB7
User NOte:
Optimal dilutions for each application to be determined by the researcher.