SGOL2 Antibody
| Code | Size | Price |
|---|
| PSI-60-874-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Shugoshin-like 2, Shugoshin-2, Sgo2, Tripin, SGOL2
Application Note:
For WB starting dilution is: 1:1000
Background:
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
Background References:
- Tanno, Y., et al. Genes Dev. 24(19):2169-2179(2010)
- Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
- Lee, J., et al. Nat. Cell Biol. 10(1):42-52(2008)
- Huang, H., et al. J. Cell Biol. 177(3):413-424(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.
NCBI Gene ID #:
151246
NCBI Official Name:
Shugoshin-like 2
NCBI Official Symbol:
SGOL2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
145 kDa
Protein Accession #:
Q562F6
Protein GI Number:
85542144
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q562F6
User NOte:
Optimal dilutions for each application to be determined by the researcher.