DHPS Antibody
| Code | Size | Price |
|---|
| PSI-58-908-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Deoxyhypusine synthase, DHS, DHPS, DS
Application Note:
For WB starting dilution is: 1:1000
Background:
The unusual amino acid hypusine is formed
posttranslationally and is only found in a single cellular protein,
eukaryotic translation initiation factor 5A. In the first step of
hypusine biosynthesis, deoxyhypusine synthase catalyzes the
NAD-dependent transfer of the butylamine moiety of spermidine to
the epsilon-amino group of a specific lysine residue of the EIF5A
precursor protein to form the intermediate deoxyhypusine residue.
This gene consists of nine exons spanning 6.6 kb. Three transcript
variants have been isolated. However, only transcript variant 1
encodes an active protein. The shorter variants may act as
modulating factors of DHPS activity.
Background References:
- Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
- Alker, A.P., et al. Trop. Med. Int. Health 13(11):1384-1391(2008)
- Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
- Lamesch, P., et al. Genomics 89(3):307-315(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DHPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human DHPS.
NCBI Gene ID #:
1725
NCBI Official Name:
Deoxyhypusine synthase
NCBI Official Symbol:
DHPS
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
P49366
Protein GI Number:
1352267
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
P49366
User NOte:
Optimal dilutions for each application to be determined by the researcher.