RNF6 Antibody

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ProSci
Product Code: PSI-60-356
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-60-356-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in A549 cell line lysates (35ug/lane).
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Western blot analysis in A549 cell line lysates (35ug/lane).

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Further Information

Additional Names:
E3 ubiquitin-protein ligase RNF6, 632-, RNF6, SPG2
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
Background References:
  • Xu, K., et al. Cancer Cell 15(4):270-282(2009)
  • Zhu, L., et al. Sci. China, C, Life Sci. 51(4):302-307(2008)
  • Tursun, B., et al. Genes Dev. 19(19):2307-2319(2005)
  • Lo, H.S., et al. Cancer Res. 62(15):4191-4193(2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RNF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529-558 amino acids from the C-terminal region of human RNF6.
NCBI Gene ID #:
6049
NCBI Official Name:
E3 ubiquitin-protein ligase RNF6
NCBI Official Symbol:
RNF6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
78 kDa
Protein Accession #:
Q9Y252
Protein GI Number:
13124536
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q9Y252
User NOte:
Optimal dilutions for each application to be determined by the researcher.