PRCP Antibody
| Code | Size | Price |
|---|
| PSI-57-023-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Lysosomal Pro-X carboxypeptidase, Angiotensinase C, Lysosomal carboxypeptidase C, Proline carboxypeptidase, Prolylcarboxypeptidase, PRCP, PRCP, PCP
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a lysosomal
prolylcarboxypeptidase, which cleaves C-terminal amino acids linked
to proline in peptides such as angiotension II, III and
des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the
enzyme activity is retained with some substrates at neutral pH.
This enzyme has been shown to be an activator of the cell
matrix-associated prekallikrein. The importance of angiotension II,
one of the substrates of this enzyme, in regulating blood pressure
and electrolyte balance suggests that this gene may be related to
essential hypertension. Alternatively spliced transcript variants
encoding distinct isoforms have been observed. [provided by
RefSeq].
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Zhao, X., et al. Proteomics 10(15):2882-2886(2010)
- Abeywickrema, P.D., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 66 (PT 6), 702-705 (2010) :
- Soisson, S.M., et al. BMC Struct. Biol. 10, 16 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PRCP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-143 amino acids from the N-terminal region of human PRCP.
NCBI Gene ID #:
5547
NCBI Official Name:
Lysosomal Pro-X carboxypeptidase
NCBI Official Symbol:
PRCP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
56 kDa
Protein Accession #:
P42785
Protein GI Number:
1172047
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
P42785
User NOte:
Optimal dilutions for each application to be determined by the researcher.