UMOD Antibody
| Code | Size | Price |
|---|
| PSI-57-596-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Uromodulin, Tamm-Horsfall urinary glycoprotein, THP, Uromodulin, secreted form, UMOD
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes uromodulin, the most abundant protein in
normal urine. Its excretion in urine follows proteolytic cleavage
of the ectodomain of its glycosyl phosphatidylinosital-anchored
counterpart that is situated on the luminal cell surface of the
loop of Henle. Uromodulin may act as a constitutive inhibitor of
calcium crystallization in renal fluids. Excretion of uromodulin in
urine may provide defense against urinary tract infections caused
by uropathogenic bacteria. Defects in this gene are associated with
the autosomal dominant renal disorders medullary cystic kidney
disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy
(FJHN). These disorders are characterized by juvenile onset of
hyperuricemia, gout, and progressive renal failure. While several
transcript variants may exist for this gene, the full-length
natures of only two have been described to date. These two
represent the major variants of this gene and encode the same
isoform.
Background References:
- Mollsten, A., et al. Scand. J. Urol. Nephrol. 44(6):438-444(2010)
- Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Gudbjartsson, D.F., et al. PLoS Genet.(7), E1001039 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This UMOD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-380 amino acids from the Central region of human UMOD.
NCBI Gene ID #:
7369
NCBI Official Name:
Uromodulin
NCBI Official Symbol:
UMOD
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
70 kDa
Protein Accession #:
P07911
Protein GI Number:
137116
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
P07911
User NOte:
Optimal dilutions for each application to be determined by the researcher.