GNE Antibody
Code | Size | Price |
---|
PSI-56-322-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acetylmannosamine kinase, ManAc kinase, GNE, GLCNE
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a bifunctional enzyme
that initiates and regulates the biosynthesis of N-acetylneuraminic
acid (NeuAc), a precursor of sialic acids. It is a rate-limiting
enzyme in the sialic acid biosynthetic pathway. Sialic acid
modification of cell surface molecules is crucial for their
function in many biologic processes, including cell adhesion and
signal transduction. Differential sialylation of cell surface
molecules is also implicated in the tumorigenicity and metastatic
behavior of malignant cells. Mutations in this gene are associated
with sialuria, autosomal recessive inclusion body myopathy, and
Nonaka myopathy. Alternative splicing of this gene results in
transcript variants encoding different isoforms. [provided by
RefSeq].
Background References:
- Stober, A., et al. Neuromuscul. Disord. 20(5):335-336(2010)
- Reinke, S.O., et al. Glycoconj. J. 26(4):415-422(2009)
- Tong, Y., et al. PLoS ONE(10), E7165 (2009) :
- Reinke, S.O., et al. FEBS Lett. 581(17):3327-3331(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Hamster, Mouse, Rat
Immunogen:
This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-197 amino acids from the N-terminal region of human GNE.
NCBI Gene ID #:
10020
NCBI Official Name:
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
NCBI Official Symbol:
GNE
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
79 kDa
Protein Accession #:
Q9Y223
Protein GI Number:
45476991
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q9Y223
User NOte:
Optimal dilutions for each application to be determined by the researcher.