CA1 Antibody
| Code | Size | Price |
|---|
| PSI-56-562-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Carbonic anhydrase 1, Carbonate dehydratase I, Carbonic anhydrase B, CAB, Carbonic anhydrase I, CA-I, CA1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
Carbonic anhydrases (CAs) are a large family of zinc
metalloenzymes that catalyze the reversible hydration of carbon
dioxide. They participate in a variety of biological processes,
including respiration, calcification, acid-base balance, bone
resorption, and the formation of aqueous humor, cerebrospinal
fluid, saliva, and gastric acid. They show extensive diversity in
tissue distribution and in their subcellular localization. CA1 is
closely linked to CA2 and CA3 genes on chromosome 8, and it encodes
a cytosolic protein which is found at the highest level in
erythrocytes. Variants of this gene have been described in some
populations. Multiple alternatively spliced variants, encoding the
same protein, have been identified. Transcript variants of CA1
utilizing alternative polyA_sites have been described in
literature.
Background References:
- Abhary, S., et al. Mol. Vis. 15, 1179-1184 (2009) :
- Gambhir, K.K., et al. Biochem. Genet. 45 (5-6), 431-439 (2007) :
- Temperini, C., et al. Bioorg. Med. Chem. Lett. 17(8):2210-2215(2007)
- Temperini, C., et al. Bioorg. Med. Chem. Lett. 16(19):5152-5156(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids from the N-terminal region of human CA1.
NCBI Gene ID #:
759
NCBI Official Name:
Carbonic anhydrase 1
NCBI Official Symbol:
CA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
Protein Accession #:
P00915
Protein GI Number:
115449
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle
Swissprot #:
P00915
User NOte:
Optimal dilutions for each application to be determined by the researcher.