FBXW11 Antibody
| Code | Size | Price |
|---|
| PSI-55-709-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
F-box/WD repeat-containing protein 11, F-box and WD repeats protein beta-TrCP2, F-box/WD repeat-containing protein 1B, Homologous to Slimb protein, HOS, FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Background:
This gene encodes a member of the F-box protein family
which is characterized by an approximately 40 amino acid motif, the
F-box. The F-box proteins constitute one of the four subunits of
ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
which function in phosphorylation-dependent ubiquitination. The
F-box proteins are divided into 3 classes: Fbws containing WD-40
domains, Fbls containing leucine-rich repeats, and Fbxs containing
either different protein-protein interaction modules or no
recognizable motifs. The protein encoded by this gene belongs to
the Fbws class and, in addition to an F-box, contains multiple WD40
repeats. This gene contains at least 14 exons, and its alternative
splicing generates 3 transcript variants diverging at the
presence/absence of two alternate exons.
Background References:
- Peschiaroli, A., et al. Oncogene 29(9):1384-1393(2010)
- Lievens, S., et al. J. Proteome Res. 8(2):877-886(2009)
- Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
- Peschiaroli, A., et al. Mol. Cell 23(3):319-329(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This FBXW11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the Central region of human FBXW11.
NCBI Gene ID #:
23291
NCBI Official Name:
F-box/WD repeat-containing protein 11
NCBI Official Symbol:
FBXW11
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
62 kDa
Protein Accession #:
Q9UKB1
Protein GI Number:
13124267
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q9UKB1
User NOte:
Optimal dilutions for each application to be determined by the researcher.