CPN1 Antibody
| Code | Size | Price |
|---|
| PSI-56-714-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Carboxypeptidase N catalytic chain, CPN, Anaphylatoxin inactivator, Arginine carboxypeptidase, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit, Kininase-1, Lysine carboxypeptidase, Plasma carboxypeptidase B, Serum carboxypeptidase N, SCPN, CPN1, ACBP
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
Carboxypeptidase N is a plasma metallo-protease that
cleaves basic amino acids from the C terminal of peptides and
proteins. The enzyme is important in the regulation of peptides
like kinins and anaphylatoxins, and has also been known as
kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer
comprised of two identical regulatory subunits and two identical
catalytic subunits; this gene encodes the catalytic subunit.
Mutations in this gene can be associated with angioedema or chronic
urticaria resulting from carboxypeptidase N deficiency. [provided
by RefSeq].
Background References:
- Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
- Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)
- Du, X.Y., et al. J. Biol. Chem. 284(2):751-758(2009)
- Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the Central region of human CPN1.
NCBI Gene ID #:
1369
NCBI Official Name:
Carboxypeptidase N catalytic chain
NCBI Official Symbol:
CPN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
52 kDa
Protein Accession #:
P15169
Protein GI Number:
115896
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle
Swissprot #:
P15169
User NOte:
Optimal dilutions for each application to be determined by the researcher.