ERVWE1 Antibody
| Code | Size | Price |
|---|
| PSI-58-894-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1
Application Note:
For WB starting dilution is: 1:1000
Background:
Many different human endogenous retrovirus (HERV) families
are expressed in normal placental tissue at high levels, suggesting
that HERVs are functionally important in reproduction. This gene is
part of an HERV provirus on chromosome 7 that has inactivating
mutations in the gag and pol genes. This gene is the envelope
glycoprotein gene which appears to have been selectively preserved.
The gene's protein product is expressed in the placental
syncytiotrophoblast and is involved in fusion of the
cytotrophoblast cells to form the syncytial layer of the placenta.
The protein has the characteristics of a typical retroviral
envelope protein, including a furin cleavage site that separates
the surface (SU) and transmembrane (TM) proteins which form a
heterodimer. Alternatively spliced transcript variants encoding the
same protein have been found for this gene.
Background References:
- Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
- Oppelt, P., et al. Gynecol. Endocrinol. 25(11):741-747(2009)
- Gimenez, J., et al. DNA Res. 16(4):195-211(2009)
- Larsen, J.M., et al. Cancer Lett. 280(1):44-49(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ERVWE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-521 amino acids from the C-terminal region of human ERVWE1.
NCBI Gene ID #:
30816
NCBI Official Name:
Syncytin-1
NCBI Official Symbol:
ERVW-1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
Q9UQF0
Protein GI Number:
47605755
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Cell Cycle,
Swissprot #:
Q9UQF0
User NOte:
Optimal dilutions for each application to be determined by the researcher.