CD320 Antibody
| Code | Size | Price |
|---|
| PSI-56-874-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A
Application Note:
For WB starting dilution is: 1:1000
Background:
The CD320 antigen gene encodes the transcobalamin receptor
(TCBLR). Cellular uptake of cobalamin (vitamin B12) is mediated by
receptors expressed on the cell surface. Transcobalamin II (TCN2;
MIM 613441), a plasma protein secreted by endothelial cells, binds
the cobalamin absorbed in the distal ileum and carries 10 to 30% of
total circulating cobalamin. CD320 encodes a transcobalamin
receptor that binds TCN2-cobalamin at the plasma membrane and
internalizes the complex by endocytosis (Quadros et al., 2009
[PubMed 18779389]).
Background References:
- Jiang, W., et al. Gene 466 (1-2), 49-55 (2010) :
- Pangilinan, F., et al. J. Med. Genet. 47(10):677-685(2010)
- Quadros, E.V., et al. Hum. Mutat. 31(8):924-929(2010)
- Quadros, E.V., et al. Blood 113(1):186-192(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CD320 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the C-terminal region of human CD320.
NCBI Gene ID #:
51293
NCBI Official Name:
CD320 antigen
NCBI Official Symbol:
CD320
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
Protein Accession #:
Q9NPF0
Protein GI Number:
74734303
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Cell Cycle,Immunology
Swissprot #:
Q9NPF0
User NOte:
Optimal dilutions for each application to be determined by the researcher.