LMNA Antibody
| Code | Size | Price |
|---|
| PSI-59-797-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1
Application Note:
For WB starting dilution is: 1:1000
Background:
The nuclear lamina consists of a two-dimensional matrix of
proteins located next to the inner nuclear membrane. The lamin
family of proteins make up the matrix and are highly conserved in
evolution. During mitosis, the lamina matrix is reversibly
disassembled as the lamin proteins are phosphorylated. Lamin
proteins are thought to be involved in nuclear stability, chromatin
structure and gene expression. Vertebrate lamins consist of two
types, A and B. Through alternate splicing, this gene encodes three
type A lamin isoforms. Mutations in this gene lead to several
diseases: Emery-Dreifuss muscular dystrophy, familial partial
lipodystrophy, limb girdle muscular dystrophy, dilated
cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford
progeria syndrome.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Wegner, L., et al. J. Clin. Endocrinol. Metab. 95(8):3884-3892(2010)
- Drac, H., et al. Neurol. Neurochir. Pol. 44(3):291-296(2010)
- Liu, Q., et al. PLoS ONE(5), E10874 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the Central region of human LMNA.
NCBI Gene ID #:
4000
NCBI Official Name:
Prelamin-A/C
NCBI Official Symbol:
LMNA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
74 kDa
Protein Accession #:
P02545
Protein GI Number:
125962
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Cell Cycle,Signal Transduction
Swissprot #:
P02545
User NOte:
Optimal dilutions for each application to be determined by the researcher.