TPSAB1 Antibody
| Code | Size | Price |
|---|
| PSI-61-930-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
Tryptases comprise a family of trypsin-like serine
proteases, the peptidase family S1. Tryptases are enzymatically
active only as heparin-stabilized tetramers, and they are resistant
to all known endogenous proteinase inhibitors. Several tryptase
genes are clustered on chromosome 16p13.3. These genes are
characterized by several distinct features. They have a highly
conserved 3' UTR and contain tandem repeat sequences at the 5'
flank and 3' UTR which are thought to play a role in regulation of
the mRNA stability. These genes have an intron immediately upstream
of the initiator Met codon, which separates the site of
transcription initiation from protein coding sequence. This feature
is characteristic of tryptases but is unusual in other genes. The
alleles of this gene exhibit an unusual amount of sequence
variation, such that the alleles were once thought to represent two
separate genes, alpha and beta 1. Beta tryptases appear to be the
main isoenzymes expressed in mast cells; whereas in basophils,
alpha tryptases predominate. Tryptases have been implicated as
mediators in the pathogenesis of asthma and other allergic and
inflammatory disorders.
Background References:
- Trivedi, N.N., et al. J. Allergy Clin. Immunol. 124(5):1099-1105(2009)
- Radhakrishnan, Y., et al. Biol. Reprod. 81(4):647-656(2009)
- Schiemann, F., et al. J. Immunol. 183(4):2223-2231(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TPSAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-87 amino acids from the Central region of human TPSAB1.
NCBI Gene ID #:
7177
NCBI Official Name:
Tryptase alpha/beta-1
NCBI Official Symbol:
TPSAB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
31 kDa
Protein Accession #:
Q15661
Protein GI Number:
18202508
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Immunology,Obesity,Signal Transduction
Swissprot #:
Q15661
User NOte:
Optimal dilutions for each application to be determined by the researcher.