PACRG Antibody
| Code | Size | Price |
|---|
| PSI-59-356-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Parkin coregulated gene protein, Molecular chaperone/chaperonin-binding protein, PARK2 coregulated gene protein, PACRG, GLUP
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a protein that is conserved across
metazoans. In vertebrates, this gene is linked in a head-to-head
arrangement with the adjacent parkin gene, which is associated with
autosomal recessive juvenile Parkinson's disease. These genes are
co-regulated in various tissues and they share a bi-directional
promoter. Both genes are associated with susceptibility to leprosy.
The parkin co-regulated gene protein forms a large molecular
complex with chaperones, including heat shock proteins 70 and 90,
and chaperonin components. This protein is also a component of Lewy
bodies in Parkinson's disease patients, and it suppresses unfolded
Pael receptor-induced neuronal cell death. Multiple transcript
variants encoding different isoforms have been found for this gene.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Wilson, G.R., et al. Fertil. Steril. 93(7):2262-2268(2010)
- Dagda, R.K., et al. J. Bioenerg. Biomembr. 41(6):473-479(2009)
- Velez, D.R., et al. Int. J. Tuberc. Lung Dis. 13(9):1068-1076(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PACRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human PACRG.
NCBI Gene ID #:
135138
NCBI Official Name:
Parkin coregulated gene protein
NCBI Official Symbol:
PACRG
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
Protein Accession #:
Q96M98
Protein GI Number:
77416872
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Neuroscience
Swissprot #:
Q96M98
User NOte:
Optimal dilutions for each application to be determined by the researcher.