SIAH1 Antibody
| Code | Size | Price |
|---|
| PSI-58-452-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
E3 ubiquitin-protein ligase SIAH1, 632-, Seven in absentia homolog 1, Siah-1, Siah-1a, SIAH1, HUMSIAH
Application Note:
For WB starting dilution is: 1:1000
Background:
SIAH1 is a protein that is a member of the seven
in absentia homolog (SIAH) family. The protein is an E3 ligase and
is involved in ubiquitination and proteasome-mediated degradation
of specific proteins. The activity of this ubiquitin ligase has
been implicated in the development of certain forms of Parkinson's
disease, the regulation of the cellular response to hypoxia and
induction of apoptosis. Alternative splicing results in several
additional transcript variants, some encoding different isoforms
and others that have not been fully characterized. [provided by
RefSeq].
Background References:
- Wu, H., et al. Biochem. Biophys. Res. Commun. 397(3):391-396(2010)
- Wen, Y.Y., et al. Mol. Carcinog. 49(5):440-449(2010)
- Dimitrova, Y.N., et al. J. Biol. Chem. 285(18):13507-13516(2010)
- Bruzzoni-Giovanelli, H., et al. J. Exp. Clin. Cancer Res. 29, 10 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SIAH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-120 amino acids from the Central region of human SIAH1.
NCBI Gene ID #:
6477
NCBI Official Name:
E3 ubiquitin-protein ligase SIAH1
NCBI Official Symbol:
SIAH1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
31 kDa
Protein Accession #:
Q8IUQ4
Protein GI Number:
46577493
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Neuroscience
Swissprot #:
Q8IUQ4
User NOte:
Optimal dilutions for each application to be determined by the researcher.