RNF19A Antibody
| Code | Size | Price |
|---|
| PSI-57-576-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
E3 ubiquitin-protein ligase RNF19A, 632-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded this gene contains two RING-finger
motifs and an IBR (in between RING fingers) motif. This protein is
an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a
characteristic neuronal inclusion in Parkinson's disease (PD)
brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8,
but not other ubiquitin-conjugating enzymes. This protein is found
to bind and ubiquitylate synphilin 1 (SNCAIP), which is a
interacting protein of alpha synuclein in neurons, and a major
component of LB. Alternatively spliced transcript variants encoding
the same protein have been reported.
Background References:
- Huh, J.W., et al. Gene 424 (1-2), 63-70 (2008) :
- Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
- Ishigaki, S., et al. Neurobiol. Dis. 25(2):331-341(2007)
- Huang, Y., et al. J. Biol. Chem. 281(17):11610-11617(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Pig
Immunogen:
This RNF19A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A.
NCBI Gene ID #:
25897
NCBI Official Name:
E3 ubiquitin-protein ligase RNF19A
NCBI Official Symbol:
RNF19A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
91 kDa
Protein Accession #:
Q9NV58
Protein GI Number:
116242764
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Neuroscience
Swissprot #:
Q9NV58
User NOte:
Optimal dilutions for each application to be determined by the researcher.