TGIF1 Antibody
| Code | Size | Price |
|---|
| PSI-57-827-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the
three-amino acid loop extension (TALE) superclass of atypical
homeodomains. TALE homeobox proteins are highly conserved
transcription regulators. This particular homeodomain binds to a
previously characterized retinoid X receptor responsive element
from the cellular retinol-binding protein II promoter. In addition
to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha
transcription activation of the retinoic acid responsive element,
the protein is an active transcriptional co-repressor of SMAD2 and
may participate in the transmission of nuclear signals during
development and in the adult. Mutations in this gene are associated
with holoprosencephaly type 4, which is a structural anomaly of the
brain. Alternative splicing has been observed at this locus and
eight variants, encoding four distinct isoforms, are described.
Background References:
- Bengoechea-Alonso, M.T., et al. Oncogene 29(38):5322-5328(2010)
- Paulussen, A.D., et al. Eur. J. Hum. Genet. 18(9):999-1005(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
- Demange, C., et al. Mol. Cell 36(6):1073-1085(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human TGIF1.
NCBI Gene ID #:
7050
NCBI Official Name:
Homeobox protein TGIF1
NCBI Official Symbol:
TGIF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
43 kDa
Protein Accession #:
Q15583
Protein GI Number:
215274200
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Neuroscience,Signal Transduction
Swissprot #:
Q15583
User NOte:
Optimal dilutions for each application to be determined by the researcher.