PUS10 Antibody
| Code | Size | Price |
|---|
| PSI-60-817-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Putative tRNA pseudouridine synthase Pus10, 5499-, Coiled-coil domain-containing protein 139, tRNA pseudouridine 55 synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase, PUS10, CCDC139, DOBI
Application Note:
For WB starting dilution is: 1:1000
Background:
Pseudouridination, the isomerization of uridine to
pseudouridine, is the most common posttranscriptional nucleotide
modification found in RNA and is essential for biologic functions
such as spliceosome biogenesis. Pseudouridylate synthases, such as
PUS10, catalyze pseudouridination of structural RNAs, including
transfer, ribosomal, and splicing RNAs. These enzymes also act as
RNA chaperones, facilitating the correct folding and assembly of
tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by
OMIM].
Background References:
- Dick, D.M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
- McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
- Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
- Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PUS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human PUS10.
NCBI Gene ID #:
150962
NCBI Official Name:
Putative tRNA pseudouridine synthase Pus10
NCBI Official Symbol:
PUS10
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
Q3MIT2
Protein GI Number:
121942830
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity
Swissprot #:
Q3MIT2
User NOte:
Optimal dilutions for each application to be determined by the researcher.