PARP1 Antibody
| Code | Size | Price |
|---|
| PSI-60-741-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Poly [ADP-ribose] polymerase 1, PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, PARP1, ADPRT, PPOL
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a chromatin-associated enzyme,
poly(ADP-ribosyl)transferase, which modifies various nuclear
proteins by poly(ADP-ribosyl)ation. The modification is dependent
on DNA and is involved in the regulation of various important
cellular processes such as differentiation, proliferation, and
tumor transformation and also in the regulation of the molecular
events involved in the recovery of cell from DNA damage. In
addition, this enzyme may be the site of mutation in Fanconi
anemia, and may participate in the pathophysiology of type I
diabetes.
Background References:
- Majewski, P.M., et al. J. Biol. Chem. 285(45):34828-34838(2010)
- Kim, M., et al. Cancer Sci. 101(11):2436-2442(2010)
- Dong, Y., et al. Cancer Res. 70(20):8088-8096(2010)
- Krishnakumar, R., et al. Mol. Cell 39(5):736-749(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This PARP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-618 amino acids from the Central region of human PARP1.
NCBI Gene ID #:
142
NCBI Official Name:
Poly [ADP-ribose] polymerase 1
NCBI Official Symbol:
PARP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
113 kDa
Protein Accession #:
P09874
Protein GI Number:
130781
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity
Swissprot #:
P09874
User NOte:
Optimal dilutions for each application to be determined by the researcher.