MDM4 Antibody
| Code | Size | Price |
|---|
| PSI-57-314-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protein Mdm4, Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, MDM4, MDMX
Application Note:
For WB starting dilution is: 1:1000
Background:
The human MDM4 gene, which plays a role in apoptosis,
encodes a 490-amino acid protein containing a RING finger domain
and a putative nuclear localization signal. The MDM4 putative
nuclear localization signal, which all Mdm proteins contain, is
located in the C-terminal region of the protein. The mRNA is
expressed at a high level in thymus and at lower levels in all
other tissues tested. MDM4 protein produced by in vitro translation
interacts with p53 via a binding domain located in the N-terminal
region of the MDM4 protein. MDM4 shows significant structural
similarity to p53-binding protein MDM2. Two transcript variants,
one protein-coding and the other likely not to be protein-coding,
have been found for this gene.
Background References:
- Xu, N., et al. Biochem. Biophys. Res. Commun. 401(3):417-421(2010)
- Sarkari, F., et al. J. Mol. Biol. 402(5):825-837(2010)
- Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MDM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human MDM4.
NCBI Gene ID #:
4194
NCBI Official Name:
Protein Mdm4
NCBI Official Symbol:
MDM4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Protein Accession #:
O15151
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity
Swissprot #:
O15151
User NOte:
Optimal dilutions for each application to be determined by the researcher.