SFTPB Antibody
| Code | Size | Price |
|---|
| PSI-58-400-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Pulmonary surfactant-associated protein B, SP-B, 18 kDa pulmonary-surfactant protein, 6 kDa protein, Pulmonary surfactant-associated proteolipid SPL(Phe), SFTPB, SFTP3
Application Note:
For WB starting dilution is: 1:1000
Background:
SFTPB is the pulmonary-associated surfactant
protein B (SPB), an amphipathic surfactant protein essential for
lung function and homeostasis after birth. Pulmonary surfactant is
a surface-active lipoprotein complex composed of 90% lipids and 10%
proteins which include plasma proteins and apolipoproteins SPA,
SPB, SPC and SPD. The surfactant is secreted by the alveolar cells
of the lung and maintains the stability of pulmonary tissue by
reducing the surface tension of fluids that coat the lung. The SPB
enhances the rate of spreading and increases the stability of
surfactant monolayers in vitro. Multiple mutations in this gene
have been identified, which cause pulmonary surfactant metabolism
dysfunction type 1, also called pulmonary alveolar proteinosis due
to surfactant protein B deficiency, and are associated with fatal
respiratory distress in the neonatal period. Alternatively spliced
transcript variants encoding the same protein have been identified.
Background References:
- Baekvad-Hansen, M., et al. Eur. Respir. J. (2010) In press :
- Kim, W.J., et al. Eur. Respir. J. (2010) In press :
- Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
- Cho, M.H., et al. Respir. Res. 11, 30 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SFTPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-158 amino acids from the Central region of human SFTPB.
NCBI Gene ID #:
6439
NCBI Official Name:
Pulmonary surfactant-associated protein B
NCBI Official Symbol:
SFTPB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
P07988
Protein GI Number:
131418
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity,Signal Transduction
Swissprot #:
P07988
User NOte:
Optimal dilutions for each application to be determined by the researcher.