SRRT Antibody
| Code | Size | Price |
|---|
| PSI-59-057-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, SRRT, ARS2, ASR2
Application Note:
For WB starting dilution is: 1:1000
Background:
SRRT acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and RNASEN, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
Background References:
- Eijgelsheim, M., et al. Hum. Mol. Genet. 19(19):3885-3894(2010)
- Kiriyama, M., et al. Mol. Cell. Biol. 29(17):4729-4741(2009)
- Gruber, J.J., et al. Cell 138(2):328-339(2009)
- Wilson, M.D., et al. Mol. Cell. Biol. 28(5):1503-1514(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This SRRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-81 amino acids from the N-terminal region of human SRRT.
NCBI Gene ID #:
51593
NCBI Official Name:
Serrate RNA effector molecule homolog
NCBI Official Symbol:
SRRT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
101 kDa
Protein Accession #:
Q9BXP5
Protein GI Number:
20137457
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity,Signal Transduction
Swissprot #:
Q9BXP5
User NOte:
Optimal dilutions for each application to be determined by the researcher.