APOBEC3A Antibody
| Code | Size | Price |
|---|
| PSI-60-931-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA dC->dU-editing enzyme APOBEC-3A, A3A, 354-, Phorbolin-1, APOBEC3A
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is a member of the cytidine deaminase gene
family. It is one of seven related genes or pseudogenes found in a
cluster, thought to result from gene duplication, on chromosome 22.
Members of the cluster encode proteins that are structurally and
functionally related to the C to U RNA-editing cytidine deaminase
APOBEC1. The protein encoded by this gene lacks the zinc binding
activity of other family members. The protein plays a role in
immunity, by restricting transmission of foreign DNA such as
viruses. One mechanism of foreign DNA restriction is deamination of
foreign double-stranded DNA cytidines to uridines, which leads to
DNA degradation. However, other mechanisms are also thought to be
involved, as anti-viral effect is not dependent on deaminase
activity. One allele of this gene results from the deletion of
approximately 29.5 kb of sequence between this gene, APOBEC3A, and
the adjacent gene APOBEC3B. The breakpoints of the deletion are
within the two genes, so the deletion allele is predicted to have
the promoter and coding region of APOBEC3A, but the 3' UTR of
APOBEC3B.
Background References:
- Thielen, B.K., et al. J. Biol. Chem. 285(36):27753-27766(2010)
- Berger, A., et al. J. Biol. Chem. 285(16):12248-12254(2010)
- Stenglein, M.D., et al. Nat. Struct. Mol. Biol. 17(2):222-229(2010)
- Abe, H., et al. Hepatol. Res. 39(12):1159-1168(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This APOBEC3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human APOBEC3A.
NCBI Gene ID #:
100913187, 200315
NCBI Official Name:
DNA dC->dU-editing enzyme APOBEC-3A
NCBI Official Symbol:
APOBEC3A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
23 kDa
Protein Accession #:
P31941
Protein GI Number:
12644206
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity,Signal Transduction
Swissprot #:
P31941
User NOte:
Optimal dilutions for each application to be determined by the researcher.