MBTPS2 Antibody
Code | Size | Price |
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PSI-56-769-400ul | 400ul | £626.00 |
Quantity:
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane protease, MBTPS2, S2P
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a intramembrane zinc metalloprotease,
which is essential in development. This protease functions in the
signal protein activation involved in sterol control of
transcription and the ER stress response. Mutations in this gene
have been associated with ichthyosis follicularis with atrichia and
photophobia (IFAP syndrome); IFAP syndrome has been quantitatively
linked to a reduction in cholesterol homeostasis and ER stress
response.
Background References:
- Ming, A., et al. Pediatr Dermatol 26(4):427-431(2009)
- Oeffner, F., et al. Am. J. Hum. Genet. 84(4):459-467(2009)
- Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
- Shen, J., et al. J. Biol. Chem. 279(41):43046-43051(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human MBTPS2.
NCBI Gene ID #:
51360
NCBI Official Name:
Membrane-bound transcription factor site-2 protease
NCBI Official Symbol:
MBTPS2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
O43462
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity,Signal Transduction
Swissprot #:
O43462
User NOte:
Optimal dilutions for each application to be determined by the researcher.