UGDH Antibody
| Code | Size | Price |
|---|
| PSI-56-538-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH, UGDH
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded by this gene converts UDP-glucose to
UDP-glucuronate and thereby participates in the biosynthesis of
glycosaminoglycans such as hyaluronan, chondroitin sulfate, and
heparan sulfate. These glycosylated compounds are common components
of the extracellular matrix and likely play roles in signal
transduction, cell migration, and cancer growth and metastasis. The
expression of this gene is up-regulated by transforming growth
factor beta and down-regulated by hypoxia. Alternative splicing
results in multiple transcript variants.
Background References:
- Wang, T.P., et al. Exp. Cell Res. 316(17):2893-2902(2010)
- Hodgkinson, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(19):8695-8700(2010)
- Huang, D., et al. Int. J. Cancer 126(2):315-327(2010)
- Lee, H.S., et al. Arch. Biochem. Biophys. 486(1):35-43(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This UGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human UGDH.
NCBI Gene ID #:
7358
NCBI Official Name:
UDP-glucose 6-dehydrogenase
NCBI Official Symbol:
UGDH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Protein Accession #:
O60701
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity,Signal Transduction
Swissprot #:
O60701
User NOte:
Optimal dilutions for each application to be determined by the researcher.